A book, website, portal and multimedia program exploring what cutting-edge technologies in personalized medicine can tell us about individual health and life -- past, present and future: genes, environment, brain and body. A joint project with the Center for Life Science Policy, University of California at Berkeley.

 
EXPERIMENTAL MAN: THE BOOK

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Experimental Man:
What one man's body reveals about his future, your health, and our toxic world
(John Wiley & Sons)
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View extensive data, information and links connected to the book by chapter or by type of data (genes, environment, brain and body)  

Book Excerpt: Contents &
  Introduction
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Featured Media Experimental Man, Discover Magazine
Part 1 : Part 2

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BODY

This page is under construction, but meanwhile below are some preliminary results and thoughts.

The "body" portion of the Experimental Man Project investigates the current status of one man's body with full-body scans and scans of organs; a proteomic assessment; a peek into microbes inside the experimental man; and advanced computer models that profile entire systems within his body.

Modeling My Heart Attack Risk with a Computer: For over a year, David has been working with computer modelers at Entelos, Inc. to develop a highly sophisticated analysis of his risk for heart attack. Below is an article from his column "Natural Selection" on Portfolio.com that summarized the Entelos Project and itís surprising results.

Experimental Man Link: For more information on the Entelos Project and details behind the science and technology used, check out the brand new website: MyDigitalHealth.com. Click on "A Personal Story".

Computing My Future Heart Attack
Predicting complex nuclear-attack scenarios used to be the, er, bomb in computer modeling. Now it's complicated human systems that test new drugs and forecast, in a first-ever test, one person's cardiac fate.
By David Ewing Duncan

Published: July 16, 2008

This wasn't supposed to happen.

In a Silicon Valley conference room I'm being told by a team of cutting-edge computer profilers that I have a 28 percent chance of having a heart attack by 2017, with my chances getting worse each year between now and then. By 2027, my risk jumps to 70 percent.

This compares with my internist's prognosis that my heart attack risk is a mere 4 percent in 10 years, a number he got during a routine checkup by matching up my cholesterol levels, age, and other factors to a scale considered state-of-the-art by most physicians.

When the profilers at Entelos, a computer bio-modeling company, agreed to test me on their advanced algorithm for predicting heart attack, they assumed my results would match up with my internist's findings.

They didn't, which suggests that the traditional assessment missed critical factors caught by the Entelos modelóa still-experimental test that the company is developing to sell as a consumer product as early as next year for patients who might be at risk for heart attack.

To create my profile, Entelos ran a series of detailed blood tests assessing everything from lipids and triglycerides to the particle size of my good and bad cholesterol (large, medium, small). I had a CT scan taken of my heart, and an ultrasound of my carotid artery in my neck, which can show a plaque buildup similar to what might be accumulating in a person's heart.

Click here for the rest of the article.

Click here for the Experimental Man power point presentation ó go through the slides to the "body" section to see a visual representation of the Entelos Project tests and charts of results.

David Gets His Full Genome Sequenced

David's Results on SNPedia: 21,556 genetic traits

Raw Genome Data

Blog: My Genome Via E-mail: Trying to understand the six billion nucleotides-all of my DNA - that just arrived in my in-box

Thanks to Complete Genomics and the Personal Genome Project



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THE EXPERIMENTAL MAN BLOG

The Experimental Man blog - hosted by MIT Technology Review.

Recent posts:

  • Welcome to a new round of Experimental Man tests!
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